Pharmacological profile and clinical effects of montelukast sodium (Singulair chewable tablet), an antiasthmatic agent.

Effects of Singulair (montelukast) treatment for capsular contracture.

BACKGROUND Capsular contracture (CC) is one of the most common complications of breast augmentation surgery. Leukotrienes are implicated in the inflammatory cascade and have been postulated to be involved in the formation of CC. Therefore, leukotriene antagonists Accolate and Singulair have been prescribed by plastic surgeons off-label to treat and prevent CC. To date, there are no studies inve...

Bioequivalence of the 4-mg Oral Granules and Chewable Tablet Formulations of Montelukast

PURPOSE: The primary objective of the studies was to demonstrate bioequivalence between the oral granules formulation and chewable tablet of montelukast in the fasted state. Effect of food on the pharmacokinetics of the oral granules was also evaluated. METHODS: The Formulation Biocomparison Study (Study 1) and the Final Market Image Study (Study 2) each used an open-label, randomized, 3-period...

Fosrenol chewable tablet ENG PAR

Formulation and evaluation of chewable modified-release tablet containing sodium fluoride and vitamin C

Chewable modified release tablets containing two active ingredients vitamin C (200mg) and Sodium Fluoride (2mg) were formulated for the treatment of dental diseases. Other ingredients include Mannitol, Carbopol and Hydroxyl-Propyl Methylcellulose (HPMC), in different ratios. These tablets were prepared by direct mixing of Hydroxypropyl Methylcellulose (HPMC), vitamin C, Sodium Fluoride, Carbopo...

Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.

Montelukast sodium [1-([(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)- ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio]methyl)cyclopropylacetic acid sodium salt] (MK-476, Singulair) is a potent and selective antagonist of the cysteinyl leukotriene (Cys-LT1) receptor and is under investigation for the treatment of bronchial asthma. To assess the metabolism and excretion of montelukast...